Nonsteroidal Ant Inflammatory Drugs-nsaids

COX-1 and COX-2 isozymes catalyze the production of eicosanoids, such as prostaglandins, prostacyclin and thromboxane from arachidonic acids. Non selective NSAIDs inhibit both COX-1 and COX-2 thus suppress the inflammatory mediators. Selective COX-2 avoid

Proton Pump Inhibitors

Proton pumps (H/K ATPase) in the parietal is the main regulator of gastric acidity. It excrete hydrogen into parietal cells in exchange of K ions. Gastrin, acetycholine and histamine H2 enhance the activity whereas prostaglandins E2 diminish the activity