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Bioavailability And Intravenous Versus Oral Administration

Bioavailability is defined as the percentage of the drug which reach systematic circulation. At steady state the intravenous administration rate equal to clearance multiply by concentration. Bioavailability of the drug affect the rate of administration of

Dosing Interval

Continuous intravenous infusion reach the steady state concentration after around 4 half-lives. Single daily intravenous injection will reach steady state after four half-lives but with more peaks and troughs. More frequent administrations results in less

Steady State Equation

At steady state the administration rate equals to elimination rate. Therefore the plasma concentration of the drug remain constant. At steady state concentration infusion rate equal to plasma concentration multiplied by clearance.