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Loading Dose

In some serious clinical conditions there is need to reach the target plasma concentration rapidly. Therefore a high dose called loading dose is given for once followed by usual maintenance dose to avoid reaching the toxic concentration

Steady State Equation

At steady state the administration rate equals to elimination rate. Therefore the plasma concentration of the drug remain constant. At steady state concentration infusion rate equal to plasma concentration multiplied by clearance.

Therapeutic Window

For any drug to exert a proper therapeutic effect, its plasma concentration must lie in target therapeutic window above the minimum therapeutic concentration and below the toxic level

Volume Of Distribution

Volume of distribution measure the ability of various drugs with different sizes and charges to distribute through body fluids. Apparent volume of distribution Vd is calculated by dividing the amount of the drug administered on the plasma concentration of