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Dopamine Balance

Dopaminergic innervation is under tight control in the nervous system. A decrease in dopaminergic innervation results in development of Parkinson disease, whereas elevation of dopaminergic activity may results in Psychotic disorders such as schizophrenia

Parkinson Disease

The main target of antiparkinsonian drugs is to increase the dopamine concentration and activity in the brain. Levodopa is transformed into dopamine in the brain, DDC and COMT inhibitors decrease the peripheral metabolism of levodopa. Dopamine agonists a