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Bioavailability And Intravenous Versus Oral Administration

Bioavailability is defined as the percentage of the drug which reach systematic circulation. At steady state the intravenous administration rate equal to clearance multiply by concentration. Bioavailability of the drug affect the rate of administration of

Steady State Equation

At steady state the administration rate equals to elimination rate. Therefore the plasma concentration of the drug remain constant. At steady state concentration infusion rate equal to plasma concentration multiplied by clearance.