Cancer and Immunity

Anticancer Drugs

Antibodies anticancer drugs inhibit the binding of cancer promoting ligands to their receptors on the cancer cells. Antimetabolites interfere with synthesis of DNA components. Microtubules inhibitors are mainly natural products. Steroid hormones agonists

General Immunosuppressant Agents

Binding of antigen presenting cells to t cells results in activation calcineurin enzyme which activate NAFTc. Active NFATc travel to nucleus and promote the release of IL-2 mRNA. The released IL-2 actiavte mTOR which enhance cellular proliferation. Cyclos

Tamoxifen

Estradiol derived from cholesterol in the adipose tissues and ovaries enhances the proliferation of breast cancer cells. Tamoxifen which is selective estrogen receptor modulator antagonize the estradiol effect on the cancer cells.