Hyperlipedemia

Bile Acid Sequestering Drugs

Large amount of cholesterol is excreted as bile acids into duodenum. However most of this bile acid is reabsorbed back to the liver through enterohepatic circulation. Bile acid sequestering drugs such as colestipol form complex with bile acids and inhibit

Fibrates

Drug for hyperlipidemia. It decreases LDL synthesis, Increases fatty acid degradation. Decreases TAG formation. Additionally it enhance synthesis of apoproteins AI and AII which result in enhancement of HDL synthesis.
Niacin
01:22

Niacin

Free fatty acids are released from adipose into blood then to hepatocytes. In the liver free fatty acids are incorporated into VLDL which is released into the blood where it transformed to LDL. Niacin anti- hyperlipidemic drug inhibit the release of free
Statins
01:45

Statins

HMG CoA enzyme inhibitors also known as statins inhibit the de novo synthesis of cholesterol in hepatic cells. Reduced cholesterol synthesis decrease the production of VLDL and LDL. Additionally low cholesterol levels in hepatocytes stimulate the producti