Emergency hypertension is defined as diastolic blood pressure higher than 110 mm Hg and associated with end organ damage such as; myocardial infarction, cerebral hemorrhage and retinal damage. Whereas in severe hypertension there is no end organ damage.
Action potential of cardial muscles (myyocytes) pass through four different phases; phase 0,1,2,3 and 4. It starts with rapid depolarization in phase 1, followed by rapid but short repolarization, then plateau in phase 2, which followed by rapid repolariz
Nitric oxide NO production in endothelial cells. Nitric oxide synthase NOS catalyze the production of NO from arginine amino acid. NO is transported into smooth muscle cells where it induce cascade of reactions ended by vasorelaxation. Nitric oxide donors
Renin angiotensin system activate the production of angiotensin II and aldosterone which induce vasoconstriction and fluid and sodium retention. These biological vascular changes results in increased blood pressure. Angiotensin converting enzyme inhibitor