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Local Anesthesia

Local anesthesia exerts its work through blocking of neuronal membrane sodium Na channels. Almost all local anesthesia are weak bases therefore they must deprotonated to its non charged form to pass through the cell membrane. In the cytoplasm they are pro

Weak Acids And Bases

The charged molecules cannot cross the phospholipid bilayer of the cell membrane, whereas the noncharged molecule can easily pass this membrane. Weak acids at its protonated form is non charge and can pass the cell membrane. However its dissociated base i