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Amphotericin B

Amphotericin B is an antifungal drug which which disturb fungal cell wall. It emerges with ergosterol and forms channels through fungal cell membrane. These channels allow the efflux of potassium K ions which results in cascade of reactions that end in ce

Azoles And Terbinafine

Ergosterol is fundamental compound in the fungal cell membrane. Both azoles and terbinafine interfere with ergosterol synthesis. Azoles inhibit the 14 α demethylase enzyme whereas terbinafine inhibit the squalene epoxidase enzyme.

General Fungal Structure

Like human fungi have cell membrane but it consists of ergosterol rather than cholesterol. Like bacteria the fungi have cell membrane but it consist of chitin not peptidoglycan. The outer layers of fungi consists of β glucans followed by protein. Formatio